N-[(R)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester
(S)-2-[(S)-(4-Nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid Isopropyl ester
CAS: 1256490-49-9
Molecular Formula: C18H21N2O7P
N-[(R)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester - Names and Identifiers
N-[(R)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester - Physico-chemical Properties
| Molecular Formula | C18H21N2O7P |
| Molar Mass | 408.34 |
| Density | 1.302±0.06 g/cm3(Predicted) |
| Melting Point | 42-43℃ |
| Boling Point | 514.3±60.0 °C(Predicted) |
| pKa | -5.78±0.70(Predicted) |
N-[(R)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester - Introduction
N-[(2-Trimethylsiloxy)-4-pyrimidine)-benzamide, also known as N-TsMPA, is an organic compound. The following is a brief description of the nature, use, preparation and safety information of the N-TsMPA:
Nature:
- N-TsMPA is a white crystalline solid, almost insoluble in water at room temperature, but soluble in organic solvents such as chloroform, methanol and dichloromethane.
-It has the structure of the functional group benzamide and pyrimidine, which makes it have certain application value in organic synthesis.
Use:
- N-TsMPA is often used as an important reagent in organic synthesis, especially as a catalyst or ligand in transition metal catalyzed reactions.
-It can be used to construct C- N bonds or amino reactions, and has been widely used in the synthesis of various organic compounds.
Method:
- N-TsMPA can be synthesized by a variety of methods. A common method is the condensation reaction of 4-pyrimidinylbenzoyl chloride (4-Py-C(O)Cl) with chloromethyl trimethylsilicate (TMSCl) under basic conditions.
Safety Information:
- N-TsMPA is generally considered safe under normal operating conditions, but as an organic compound, appropriate safety measures still need to be taken.
-Avoid contact with skin, eyes and respiratory tract, and wear appropriate personal protective equipment.
-It should be operated in a well-ventilated place and avoid contact with open flames or high temperature sources.
- N-TsMPA should be stored in a dry, cool place, away from oxidants and acids.
Nature:
- N-TsMPA is a white crystalline solid, almost insoluble in water at room temperature, but soluble in organic solvents such as chloroform, methanol and dichloromethane.
-It has the structure of the functional group benzamide and pyrimidine, which makes it have certain application value in organic synthesis.
Use:
- N-TsMPA is often used as an important reagent in organic synthesis, especially as a catalyst or ligand in transition metal catalyzed reactions.
-It can be used to construct C- N bonds or amino reactions, and has been widely used in the synthesis of various organic compounds.
Method:
- N-TsMPA can be synthesized by a variety of methods. A common method is the condensation reaction of 4-pyrimidinylbenzoyl chloride (4-Py-C(O)Cl) with chloromethyl trimethylsilicate (TMSCl) under basic conditions.
Safety Information:
- N-TsMPA is generally considered safe under normal operating conditions, but as an organic compound, appropriate safety measures still need to be taken.
-Avoid contact with skin, eyes and respiratory tract, and wear appropriate personal protective equipment.
-It should be operated in a well-ventilated place and avoid contact with open flames or high temperature sources.
- N-TsMPA should be stored in a dry, cool place, away from oxidants and acids.
Last Update：2024-04-09 02:00:41
![N-[(R)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester](http://res.chembk.com/assets/str/2d/1/12/1256490-49-9.png)